Predicting apparent passive permeability of Caco-2 and MDCK cell-monolayers: A mechanistic model
نویسندگان
چکیده
منابع مشابه
Predicting apparent passive permeability of Caco-2 and MDCK cell-monolayers: A mechanistic model
Experimentally derived apparent permeabilities, Papp, through cell monolayers such as Caco-2 and MDCK are considered to be an in-vitro gold standard for assessing the uptake efficiency of drugs. Here, we present a mechanistic model that describes 'passive' Papp values (i.e., neglecting active transport) by accounting for the different resistances solutes encounter when permeating a cell monolay...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2017
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0190319